Co-occurrence restrictions on Biblical Hebrew root consonants have received thorough treatment in the specialized literature. However, combinations involving glides on the one hand, and nominal roots on the other, have received very little attention. The aim of this paper is to argue for an incompatibility between medial consonants and final glides in defective nouns: a final w cannot generally follow a homorganic medial root consonant, viz. labial p, b, m and velar k, g, q. The III-w roots are rare: they came about as a result of a well-documented historical process and are found almost only in nominal roots. Previous investigations have overlooked this incompatibility owing to the incomplete scope of the studies.