For most of the Democratic Republic of the Congo quantitative data on bushmeat exploitation are scarce. We conducted focus group discussions on preferred species for household consumption and income generation in 24 villages around Lomami National Park, created in 2016. We also carried out a bushmeat market survey in Kindu, a major town in the study area, to estimate annual sales volumes and retail values. Villagers reported household consumption of 22 mammal species, with the most important being the African brush-tailed porcupine, Peters's duiker, bay duiker and red river hog. The latter three were also the most important for income generation. A greater number of smaller species were consumed at the household level, compared with those traded. A total of 17 mammal and one reptile species were traded in Kindu. Those traded in greater numbers were the African brush-tailed porcupine, blue and bay duiker, red river hog, red-tailed monkey and the sitatunga. We estimated > 40,000 carcasses were traded in Kindu annually, with a retail value of USD 725,000. Several species of conservation concern, such as the bonobo, were mentioned or observed. Few rodents and numerous large animals were traded in Kindu, suggesting resources have not yet been depleted. However, both villagers and urban vendors perceived a decline of many species and reported an increase in the use of firearms and the number of foreign hunters in the area. Among other interventions, we discuss how local communities could be encouraged to help preserve wildlife in the Park's buffer zone.