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3 results

  • Small cell carcinoma of the head and neck: report of three cases

  • H Matsuyama, K Yamazaki, M Tomita, S Takahashi
  • Journal:
    The Journal of Laryngology & Otology / Volume 127 / Issue 9 / September 2013
    Published online by Cambridge University Press:
    08 August 2013, pp. 942-946
    Print publication:
    September 2013
  • Objective:

    Small cell carcinoma of the head and neck is rare and has unique histopathological characteristics that make it difficult to diagnose and treat. In this report, the Japanese Lung Cancer Treatment Guidelines were adapted to treat three patients with small cell carcinoma of the head and neck, and outcomes evaluated.

    Methods:

    There was one case each of stage I small cell carcinoma of the nasal cavity, stage IV-B small cell carcinoma of the ethmoid sinus, and stage IV-A small cell carcinoma of the submandibular gland. All patients underwent chemoradiotherapy and achieved a partial response.

    Results:

    Only case one underwent surgery after chemoradiotherapy; 31 months after treatment, this patient had suffered no recurrence. Case two died three months after treatment due to bone marrow metastasis. Case three had experienced no progression after 12 months of follow up.

    Conclusion:

    In this small patient series, short-term results were equivalent to or better than usual treatment outcomes for small cell carcinoma of the lung.

  • Small cell neuroendocrine carcinoma of the nasal cavity and paranasal sinuses: a rare case

  • I P Tang, S Singh, G Krishnan, L M Looi
  • Journal:
    The Journal of Laryngology & Otology / Volume 126 / Issue 12 / December 2012
    Published online by Cambridge University Press:
    19 October 2012, pp. 1284-1286
    Print publication:
    December 2012
  • Objective:

    We report a rare case of small cell neuroendocrine carcinoma of the nasal cavity and paranasal sinuses with intracranial extension, and discuss the management of this rare tumour.

    Results:

    Small cell neuroendocrine carcinoma involving the nasal cavity and paranasal sinuses with intracranial extension may be treated successfully with surgery alone, without development of local recurrence.

    Conclusion:

    Small cell neuroendocrine carcinoma is a locally aggressive tumour with a high rate of recurrence. Early and aggressive surgical excision with or without radiotherapy or chemotherapy can improve a patient's outcome and prognosis. Regular follow up is needed to detect any local or distant recurrence.

  • Small cell neuroendocrine carcinoma of the nasal cavity and paranasal sinuses

  • E Babin, V Rouleau, P O Vedrine, B Toussaint, D de Raucourt, O Malard, A Cosmidis, M Makaeieff, D Dehesdin
  • Journal:
    The Journal of Laryngology & Otology / Volume 120 / Issue 4 / April 2006
    Published online by Cambridge University Press:
    10 March 2006, pp. 289-297
    Print publication:
    April 2006

  • Introduction: Small cell neuroendocrine carcinoma (SNEC) of the sinonasal tract is a rare disease.

    Objective: Report a descriptive study of a relatively large cohort of SNEC of the nasal cavity and paranasal sinuses.

    Method: The medical records of 21 patients presenting with nasal and paranasal SNEC to various French hospitals, from 1989 to 2003, were analysed to determine the clinical features and current treatment of the disease.

    Results: Patient data were obtained from eight French hospitals. Twelve of the patients were male and nine were female, with a mean age at presentation of 55 years (range: 27 to 79 years). Patients' staging for nasal cavity malignancy was: T1, four; T2, three; T3, one; T4, 13; N0, 18; N2, three; M0, 20; and M1, one. None of the patients suffered from SNEC of the sinonasal tract with ectopic hormone production. Immunohistochemistry proved useful for diagnosis in 20 cases. Twelve cases were positive for cytokeratin, 14 for chromogranin, eight for neuron-specific enolase and 11 for neuron-specific synaptophysin. One patient had an adenocarcinoma and an inverted papilloma associated with neuroendocrine carcinoma. Patients underwent surgery (11 cases), radiotherapy (14 cases) and chemotherapy (12 cases). Recurrence occurred in 10 cases. Five patients had visceral metastases or cervical lymph node involvement. Nine of the patients died within four years of onset of the disease.

    Conclusion: Small cell neuroendocrine carcinoma of the sinonasal tract is an uncommon neoplasm with aggressive clinical behaviour. Recurrence is frequent and the prognosis is poor. However, the current treatment of these neuroendocrine neoplasms varies widely.