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1 results

  • Hearing outcome of early postnatal exposure to hypoxia in Sprague–Dawley rats

  • S J Daniel, M McIntosh, O V Akinpelu, C V Rohlicek
  • Journal:
    The Journal of Laryngology & Otology / Volume 128 / Issue 4 / April 2014
    Published online by Cambridge University Press:
    15 April 2014, pp. 331-335
    Print publication:
    April 2014
  • Objective:

    To determine the effect of experimentally induced hypoxia, in the first 10 days of life, on physiological hearing in a Sprague–Dawley rat model.

    Methods:

    A prospective, controlled animal study was carried out using 22 male rat pups. The rats in the hypoxic group (n = 12) were reared in hypoxia for the first 10 days of life, and subsequently reared in normoxia, while those in the control group (n = 10) were reared in normoxia for the duration of the experiment. Hearing was assessed using auditory brainstem response testing at approximately 72 days of age.

    Results:

    The hypoxia group had higher auditory brainstem response thresholds for all frequencies tested (more pronounced at 16 kHz), compared with controls. Wave I–V inter-peak latencies were more prolonged in the hypoxic rats, while both groups had similar wave I latencies.

    Conclusion:

    Chronic postnatal hypoxia induced permanent hearing loss in this Sprague–Dawley rat model. Prolonged wave I–V inter-peak latencies suggested functional abnormality in the central auditory pathway.