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1 results

  • CT and MRI Abnormalities in Schizophrenia: The New Developmental Biology of Psychosis?

  • John L Waddington
  • Journal:
    Irish Journal of Psychological Medicine / Volume 6 / Issue 1 / March 1989
    Published online by Cambridge University Press:
    13 June 2014, pp. 19-22
    Print publication:
    March 1989

  • Despite more than a decade of studies, biological psychiatry has yet to satisfactorily resolve the issue of whether new brain imaging technologies reliably indicate the presence of abnormal cerebral morphology in schizophrenia. The present Perspective offers an alternative view on this topic, as a counter-point to one previously offered in the Journal. It addresses several of the methodological problems inherent to such studies, and evaluates some of the more recent aspects of the literature. Those structural abnormalities which have been reported in schizophrenia appear most readily explicable as a consequence of neurodevelopmental anomalies.