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Psychiatrists are often called to see nonpsychiatric patients in medical settings. Two potential reasons for a consult are neuroleptic malignant syndrome and serotonin syndrome; both are potential emergencies. They differ in cause and pathophysiology. However, they have certain things in common: Both are rare and may go unrecognized or misdiagnosed. In addition, the course of both syndromes depends on the speed of intervention, and delays can result in lasting complications or mortality. This chapter reviews the features of each syndrome, the diagnosis and differential, and the recommended treatment approaches.
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