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2 results

  • In vitro measurement of ciliary beat frequency in 92 children with recurrent respiratory tract problems

  • A Drake-Lee, A Green, A-L McDermott
  • Journal:
    The Journal of Laryngology & Otology / Volume 136 / Issue 12 / December 2022
    Published online by Cambridge University Press:
    10 October 2022, pp. 1183-1188
    Print publication:
    December 2022
    • Article
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  • Background

    Chronic or recurrent mucoid respiratory tract symptoms may be difficult to diagnose.

    Method

    Ninety-two children with chronic respiratory symptoms were divided into 4 groups: 18 children with refractory asthma, 10 with bronchiectasis without dextrocardia, 18 with dextrocardia and 46 with recurrent respiratory tract infections. Except for five neonates, cytology samples were taken under general anaesthesia. Ciliary beat frequency was measured photometrically and analysed by in-house computer software.

    Results

    Nasal polyps were found in one child with normal ciliary beat frequency. Twenty-six children had no beating cilia (male to female ratio, 15:11). The effect of increasing temperature on the ciliary beat frequency of the remaining 66 patients was evaluated (42 patients, more than 30°C, median, 8.3 Hz; 24 patients, 30–37°C, median, 11.8 Hz; p = 0.0003).

    Conclusion

    The measurement of ciliary beat frequency is part of the diagnostic work up of patients with persistent or recurrent respiratory tract infections.

  • Bronchiectasis and sino-nasal disease: a review

  • C M Philpott, D C McKiernan
  • Journal:
    The Journal of Laryngology & Otology / Volume 122 / Issue 1 / January 2008
    Published online by Cambridge University Press:
    25 June 2007, pp. 11-15
    Print publication:
    January 2008

  • The ‘one airway’ model for upper and lower respiratory tract disease is a concept gaining increasing momentum in both respiratory medicine and otorhinolaryngology. The specific common aetiology and pathophysiology of concomitant bronchiectasis and sino-nasal disease, such as chronic rhinosinusitis, are discussed here, as well as the clinical manifestations, along with a review of all the relevant literature in the field.