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1 results

  • 2 - Pregnancy in women with inherited bleeding disorders

  • Edited by Ann Harper
  • Book:
    Haemorrhage and Thrombosis for the MRCOG and Beyond
    Published online:
    05 October 2014
    Print publication:
    01 June 2005, pp 16-26

  • Summary

    This chapter discusses the management of pregnancy and delivery in women suffering from an inherited bleeding disorder such as von Willebrand's disease or haemophilia, or are female partners of affected men. The daughters of men with haemophilia are obligate carriers, with a 50:50 chance of passing on the condition to a son and a similar chance that a daughter will be a carrier of the condition. Chorionic villus sampling, or biopsy, is the principal method used for antenatal diagnosis of haemophilia. Deficiency of von Wille brand factor (VWF) typically results in easy bruising, prolonged bleeding from cuts and scratches, epistaxis and menorrhagia. It is prudent to check the VWF level in all women with von Willebrand's disorder a few days after delivery: an infusion of DDAVP (l-desamino-8-D-arginine vasopressin; desmopressin) may be indicated where the level falls significantly soon after delivery.