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  • 20 - Challenges in the Relationships between Psychological and Biological Phenomena in Psychopathology

  • from Section 7
  • Edited by Kenneth S. Kendler, Virginia Commonwealth University, Josef Parnas, University of Copenhagen, Peter Zachar, Auburn University, Montgomery
  • Book:
    Levels of Analysis in Psychopathology
    Published online:
    02 April 2020
    Print publication:
    02 April 2020, pp 238-266

  • Summary

    This chapter addresses three questions posed for the 2018 Copenhagen conference. We argue that reduction in the widely assumed sense of eliminating psychological constructs is not a feasible option in psychopathology research. We argue that the popular “levels of analysis” metaphor is more problematic than helpful. We argue that a recent movement in philosophy of science, known as the new mechanists, offers a promising alternative to the naïve biological reductionism that has driven much thinking and research on psychopathology in the Decades of the Brain. Finally, we evaluate the NIMH Research Domain Criteria (RDoC) initiative in the context of these three questions, citing key features that facilitate moving clinical research forward more quickly and more effectively than what has characterized the field for decades. RDoC avoids reductionism, fosters integration of psychological and biological constructs, methods, and data, and is well suited to the emerging research agenda in the psychopathology literature.