This study evaluates the strengths and weaknesses of defamilization as a concept for analysing state-market-family relationships in comparative perspective. A paradox has emerged around defamilization in the last decade; its use in empirical large-N research has grown markedly despite mounting criticism in theoretical discussions. Applying criteria of conceptual goodness, we find that the popularity of the concept is based on its high degree of parsimony, theoretical utility and field utility, but that there are problems with the resonance, coherence and differentiation of the concept. We argue that defamilization is most coherent and has greatest utility if the concept’s roots in welfare state theory are fully acknowledged. In our view, this means that defamilization is best understood a) alongside the separate concept of familization, b) as a multidimensional concept in terms of economic and social dependencies in family relationships, and c) as a means of addressing both gender and intergenerational dependencies. Although suitable for operationalization in empirical research, the concept hence imposes high demands regarding the required data and possible analyses.