This paper is concerned with the impact of ancient DNA data on our models of the Mesolithic–Neolithic transition in central Europe. Beginning with a brief overview of how genetic data have been received by archaeologists working in this area, it outlines the potential and remaining problems of this kind of evidence. As a migration around the beginning of the Neolithic now seems certain, new research foci are then suggested. One is renewed attention to the motivations and modalities of the migration process. The second is a fundamental change in attitude towards the capabilities of immigrant Neolithic populations to behave in novel and creative ways, abilities which in our transition models were long exclusively associated with hunter-gatherers.