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1 results

  • Prognostic role of epidermal growth factor-like domain 7 protein expression in laryngeal squamous cell carcinoma

  • J-J Li, X-M Yang, S-H Wang, Q-L Tang
  • Journal:
    The Journal of Laryngology & Otology / Volume 125 / Issue 11 / November 2011
    Published online by Cambridge University Press:
    07 September 2011, pp. 1152-1157
    Print publication:
    November 2011
  • Objective:

    This study aimed to retrospectively analyse the expression of epidermal growth factor-like domain 7 protein in cases of laryngeal squamous cell carcinoma.

    Methods:

    We studied 116 patients retrospectively. Expression of epidermal growth factor-like domain 7 protein was determined in tumour and nontumour tissue samples, by immunohistochemistry.

    Results:

    Expression levels were significantly increased in 94 cases. Increased expression levels correlated well with tumour stage (p = 0.001) and lymph node metastasis (p = 0.002). Log-rank survival testing showed a significant difference between patients with marked versus limited expression levels (p = 0.03). Multivariable Cox regression analysis showed that epidermal growth factor-like domain 7 protein expression level was an independent predictor of laryngeal squamous cell carcinoma prognosis.

    Conclusion:

    These findings provide evidence that increased epidermal growth factor-like domain 7 protein expression is associated with laryngeal squamous cell carcinoma stage, lymph node metastasis and poor survival. This suggests that this protein may be a potential marker for laryngeal squamous cell carcinoma.