The new species Echidnopsis inconspicua (Apocynaceae–Asclepiadoideae) and Secamone cuneifolia (Apocynaceae–Secamonoideae) are described from Socotra. An account of Echidnopsis is provided for the island, where five species are now known to occur. The first species of Ceropegia is recorded for Socotra.