Two classical stochastic processes are considered, the Ehrenfest process, introduced in 1907 in the kinetic theory of gases to describe the heat exchange between two bodies, and the Engset process, one of the early (1918) stochastic models of communication networks. In this paper we investigate the asymptotic behavior of the distributions of hitting times of these two processes when the number of particles/sources goes to infinity. Results concerning the hitting times of boundaries in particular are obtained. We rely on martingale methods; a key ingredient is an important family of simple nonnegative martingales, an analogue, for the Ehrenfest process, of the exponential martingales used in the study of random walks or of Brownian motion.

In this paper we propose a class of sequential urn designs based on generalized Pólya urn (GPU) models for balancing the allocations of two treatments in sequential clinical trials. In particular, we consider a GPU model characterized by a 2 x 2 random addition matrix with null balance (i.e. null row sums) and replacement rule depending upon the urn composition. Under this scheme, the urn process has a Markovian structure and can be regarded as a random extension of the classical Ehrenfest model. We establish almost sure convergence and asymptotic normality for the frequency of treatment allocations and show that in some peculiar cases the asymptotic variance of the design admits a natural representation based on the set of orthogonal polynomials associated with the corresponding Markov process.