The paper presents experimental and theoretical research data on the generation, transport, and extraction of a large cross-section (750 × 150 mm2) electron beam into the air through a thin metal foil in an accelerator with a mesh plasma cathode on the bases of a low-pressure arc and with a multi-aperture two-electrode electron-optical system. When the burning conditions of the arc discharge, responsible for the generation of the emission plasma, is changed, the characteristics of this plasma were investigated, including under the conditions of the selection of electrons from it. Our experiments show that at an accelerating voltage of 200 kV, current in the accelerating gap of up to 30 A, and full width at half maximum of up to 100 µm, the average extracted power is ≈4 kW and the extracted beam current is ≈85% from the common current into the accelerating gap. Our numerical estimates give a good correlation between the arc and emission plasma parameters depending on the electrode configuration in the discharge system and on the mechanism of electron beam generation. Analysis of the emission plasma parameters under different arc conditions and of the mechanisms responsible for the beam energy loss suggests that most of the energy in the accelerator is lost at the support grid and at the output foil due to defocusing of the beam and partial electron reflection from the foil. Other mechanisms that decrease the extracted beam energy are discussed.