Mormon Lake, elevation 2166 m with maximum historic surface area of 31.4 km2, lies in a forested endorheic basin covering 103 km2. It is the largest unaltered freshwater body on the 337,000 km2 Colorado Plateau. Prehistorical (before AD 1878) highstands were ca. 9 and 24 m relative to depocenter datum. These levels likely occurred during four multidecadal episodes of cool, wet conditions between ca. 3.55 and 0.20 ka BP. Maximum historical levels (early 1900s) were up to 7.9 m, whereas modern (post-1941) levels were frequently zero or relatively low. Historical climate records indicate reconstructed lake levels correlate directly with annual precipitation and inversely with temperature. Early highstands were associated with above average precipitation and the lowest temperatures of the 116 yr record. The lake receded after 1941; thereafter, frequent drying and low-water levels resulted from recurrent drought and steadily increasing temperatures. Consequently, a wet episode from the 1970s to the 1990s had precipitation like the early 1900s, but highstands were only ca. 3.8 m. The historical lake-level chronology is consistent with changes of hydrologic balance predicted by climate models, that is, reduced effective precipitation (precipitation minus evaporation). These changes, particularly aridification, apparently began in the 1970s or earlier. Global oceanic and atmospheric climate modulate lake levels and regional hydroclimate.