Relations with Assyria dominated from the tenth to the late seventh century. Marduk’s reputation was tarnished as Babylon lost power. Tribes of Chaldeans and Arameans moved into the Sealand, where some settled, becoming literate and powerful. Iron gradually replaced bronze. Fine stone carving continued. Warlike Assyrian kings venerated Babylon, incorporated its gods into their pantheon, and treated the city separately from the rest of Babylonia; but Assyria and Babylon clashed east of the Tigris at Der. Chaldeans intermittently took the throne. Tiglath-pileser III, the first Assyrian king to become king of Babylon, took part in the New Year festival; Sargon II, the second, deposed a Chaldean and deported many disloyal groups, but invested in the city. When Sennacherib ruled Assyria, various rulers of Babylon and interference from Elam ended when he sacked Babylon, which remained kingless for seven years. His patricidal son Esarhaddon made some restitution. At his early death, Esarhaddon’s elder son took the throne, dominated by his younger son, Ashurbanipal, whose library at Nineveh included many Babylonian texts. Betrayed by his brother under Elamite influence, Ashurbanipal sacked Babylon. Royal records end, and three subsequent kings are poorly attested. Nabopolassar, a Babylonian general working in the Assyrian army, defected and took the throne of Babylon.

Nabopolassar fought with an Assyrian-style army and took the throne of Babylon. Thirteen years later, Nineveh fell despite Egyptian help. Babylon took over much of the Assyrian empire. Later he defeated the last Assyrian king at Harran. His success was seen as Marduk’s revenge. Captured wealth from Assyrian royal cities allowed major building work at Babylon, which was continued by Nabopolassar’s son Nebuchadnezzar II. Neither king left statues of themselves, and cylinder seals represent gods by their symbols. Major subsidence in the citadel required frequent rebuilding on the Southern Palace. The names of temples and gates were compiled on to a clay tablet as a literary work. Colour-glazed bricks adorned the Processional Way leading to the temple of the New Year festival outside the citadel walls. That festival is described. Some of his creations Nebuchadnezzar described as a Wonder, but he made no mention of the Hanging Garden. In a separate part of the citadel, Nebuchadnezzar built a Summer Palace. His conquests included Tyre and Ashkelon but not Egypt or Lydia. He sacked the Temple in Jerusalem and deported its royal family to Babylon. Other captives settled on land nearby. Business archives of long duration continue into the Achaemenid period.

Darius I overcame rebellions and seized the throne of Babylon, but cuneiform scholarship continued and developed; religious practices did not change, nor did the great buildings on the citadel. The zodiac scheme came into use. The Achaemenid king took Babylonian royal titles and promoted the worship of Marduk for local purposes. Xerxes broke the continuity. Following an uprising, a purge led to the ending of many archives. The province of Babylon was divided in two. Subsequent Achaemenid kings continued to treat Babylon with reverence. Alexander the Great defeated Darius III, entered Babylon, retained the Persian satrap, and moved treasure from Susa and Ecbatana to Babylon. He was recognized as a god. Lack of sons at his premature death precipitated a civil war from which Alexander’s commander Seleucus emerged to take the throne jointly with his son Antiochus. The derelict ziggurat was demolished, but temples and rituals, chronicles and astronomical diaries, continued as before. Aramaic was widely used, and fewer texts were inscribed in cuneiform. Interest in the fall of Assyria and of the Babylonian empire is apparent in Greek literature. Famous scholars include Berossus and named astronomers. Parthians invaded and eventually ended the dynasty.

The First Dynasty, an unbroken succession of Amorite kings, lasted 300 years despite a major rebellion. Babylon had close relationships with the nearby cities Sippar, Kish, and Borsippa. Trade and alliances reached much further. The Sumerian king-lists of earlier times were replaced by Babylonian equivalents, various cities having their own version. Kings briefly recorded major events; names were given to each year of their reign for dating documents. Trade was widespread, by canal and river, or overland by donkey. Royal edicts excluded certain groups from trade. Evidence comes from a profusion of clay tablets. Official letters are plentiful. Priestesses of Marduk carried out trade for Babylon in other cities. The temple of Marduk was built and furnished with a golden throne. Elamite control over several major cities, which left its mark on temple design, was ended by Hammurabi late in his reign; there is a possible connection with Genesis 14:1–16. Regular edicts were issued to release individuals from debt and to regulate trade. The main powers were Halab (Aleppo), Eshnunna, and Larsa, until Hammurabi achieved supremacy and claimed divinity. His successor Samsu-iluna followed his father’s example.