Adversus haereses 3.22.4 is one of the key texts for Irenaeus’ views about the virgin Mary’s role in the “economy” of salvation. Among the many interpretative riddles of this passage, this paper discusses the function of the metaphor of the knots in Irenaeus’ argument. A close analysis suggests that the lines in question are not the conclusion of the preceding section (as implied by the Latin version—and modern interpreters), but the opening of a concluding development that sums up the role of the New Adam and the New Eve. As a result, the metaphor of knots should not be understood in exclusive connection with Mary: it applies to both Christ and her— though it is particularly fitting for expressing Mary’s role as New (and Anti-) Eve.