A group G has restricted centralizers if for each g in G the centralizer $C_G(g)$ either is finite or has finite index in G. A theorem of Shalev states that a profinite group with restricted centralizers is abelian-by-finite. In the present paper we handle profinite groups with restricted centralizers of word-values. We show that if w is a multilinear commutator word and G a profinite group with restricted centralizers of w-values, then the verbal subgroup w(G) is abelian-by-finite.