High-resolution sedimentological and geochronological investigations of paleochannel systems in the Ried Central d'Alsace (northeastern France) allow for the reconstruction of the late glacial and Holocene fluvial evolution of this section of the Upper Rhine alluvial plain. During the Oldest Dryas, the landscape featured a dominant braided Rhine system and, to a lesser extent, a braided Fecht system. The shift to the Bølling-Allerød saw a narrowing of the Rhine's active channel belt, the development of a complex channel pattern, and the genesis of the Ill River. The river channel patterns remained unchanged during the Younger Dryas. In the Early Holocene, the Rhine's active belt narrowed further, and the Rhine and Ill Rivers developed braided-anastomosing and anastomosing channel patterns, respectively. Throughout the Holocene, both rivers maintained their channel patterns while migrating east and west across the alluvial plain, respectively. In the late glacial, fluvial dynamics in this section of the Upper Rhine plain were primarily influenced by climate-related environmental and hydrogeomorphological changes. Conversely, during the Holocene, the evolution of the fluvial hydrosystems was driven by a complex interaction of climatic and non-climatic factors, including human activity at the catchment scale, alluvial plain architecture, and local neotectonics.