Tetflupyrolimet is the first herbicide with a novel site of action to be commercialized for use in agronomic crops in three decades. Direct-seed rice field experiments were conducted at research facilities near Stuttgart (silt loam), AR, and Keiser (clay), AR, to evaluate tetflupyrolimet as a preemergence herbicide versus commercial standards. Greenhouse experiments determined the influence of soil moisture on pre- and postemergence (POST) barnyardgrass control with tetflupyrolimet and clomazone, and the impact of a delayed flood on efficacy when POST-applied. For the field experiments, clomazone, tetflupyrolimet, and quinclorac were applied individually PRE at 336 and 560, 134 and 224, and 336 and 560 g ai ha-1, respectively, on a silt loam and clay soil, along with clomazone plus tetflupyrolimet and clomazone plus quinclorac at the same rates. The soil moisture experiment included a single PRE and POST application of clomazone at 336 g ai ha-1, tetflupyrolimet at 134 g ai ha-1, and a mixture at the respective rates, on a silt loam soil at 50, 75, and 100% of field capacity. For the flood timing experiment, tetflupyrolimet was applied to 2- to 3-leaf barnyardgrass at 134 g ai ha-1, and a flood was established at 4 hr after treatment (HAT) and 5 and 10 d after treatment (DAT). Barnyardgrass control with a tetflupyrolimet and clomazone mixture was comparable to clomazone plus quinclorac when averaged over all evaluations on silt loam and clay texture soils (≥91%). Soil moisture interacted with herbicide treatments for PRE and POST barnyardgrass efficacy when averaged over DAT, with tetflupyrolimet plus clomazone generally providing the greatest and most consistent control across regimes. Flooding barnyardgrass at 4 HAT provided superior control to later flood timings. Tetflupyrolimet is an effective residual barnyardgrass herbicide, and the addition of clomazone will aid in providing consistent control across varying soil moisture conditions.