An experiment was conducted at two locations in Georgia and one location in North Carolina during 1994 and 1995 to evaluate weed management systems utilizing pyrithiobac applied preemergence (PRE) in conventional-tillage bromoxynil-resistant cotton. Weed management systems evaluated included different combinations of pyrithiobac PRE, bromoxynil or bromoxynil plus MSMA applied early postemergence (EPOST), bromoxynil applied postemergence (POST), and cyanazine plus MSMA applied late postemergence-directed (LAYBY). Pyrithiobac PRE improved control of Florida beggarweed, pitted morningglory, prickly sida, sicklepod, and spurred anoda compared with systems that did not include pyrithiobac PRE. Averaged across locations, pyrithiobac PRE increased cotton lint yields 330 kg ha−1. Bromoxynil applied EPOST or POST increased weed control and cotton lint yield. Bromoxynil EPOST, POST, or EPOST plus POST did not control sicklepod. The addition of MSMA to bromoxynil EPOST improved sicklepod control. Two applications of bromoxynil controlled more pitted morningglory and sicklepod than one application. Control of all dicotyledonous weeds was increased by cyanazine plus MSMA LAYBY, and this treatment increased yields at all locations. Cotton was not injured by pyrithiobac PRE or by bromoxynil applied EPOST or POST, but temporary visual injury was observed with EPOST treatments of MSMA.