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2 results

  • Effects of Onabotulinum Toxin A on Gait in Parkinson’s Disease Patients with Foot Dystonia

  • Pei Huang, Yuan-Yuan Li, Jung E. Park, Ping Huang, Qin Xiao, Ying Wang, Sheng Chen, Sheng-Di Chen, Jun Liu, Yi-Wen Wu
  • Journal:
    Canadian Journal of Neurological Sciences / Volume 49 / Issue 1 / January 2022
    Published online by Cambridge University Press:
    09 March 2021, pp. 123-128
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  • We investigated the effects of botulinum toxin on gait in Parkinson’s disease (PD) patients with foot dystonia. Six patients underwent onabotulinum toxin A injection and were assessed by Burke–Fahn–Marsden Dystonia Rating Scale (BFMDRS), visual analog scale (VAS) of pain, Timed Up and Go (TUG), Berg Balance Test (BBT), and 3D gait analysis at baseline, 1 month, and 3 months. BFMDRS (p = 0.002), VAS (p = 0.024), TUG (p = 0.028), and BBT (p = 0.034) were improved. Foot pressures at Toe 1 (p = 0.028) and Midfoot (p = 0.018) were reduced, indicating botulinum toxin’s effects in alleviating the dystonia severity and pain and improving foot pressures during walking in PD.