The United States has the highest number of COVID-19 cases, yet many Americans have responded indifferently toward policies designed to combat the spread of the virus. While nearly all 50 states have implemented some type of stay-at-home policy to encourage social distancing, there has been high variation in the degree of compliance. We argue that this variance is partly driven by gender resentment. Gender resentment reduces trust in female political leaders and thus decreases compliance with government policy and recommendations. Using data from SafeGraph and the 2016 American National Election Study, we demonstrate that the effect of stay-at-home policies on social distancing is reduced when gender resentment increases in states with female leaders. However, when gender resentment is low, there is no difference in the effect of policies on behavior. This research has important implications for understanding unseen barriers that can mediate the efficacy of female political leaders.