A long-term integrated pest management study initiated in 1980 and continued through 1991 was conducted to determine interactions of tillage, crop rotation, and herbicide use levels on weed seed populations, weed populations, and crop yield. This paper presents giant foxtail seed population and stand along with corn yield in continuous corn, corn rotated with soybean, or corn following wheat in a soybean-wheat-corn rotation. Increasing herbicide use levels above the minimum reduced giant foxtail seed in the 0- to 2.5-cm depth of soil. Reducing tillage from conventional moldboard plowing to chiseling to no-tilling increased giant foxtail seed in only the top 0 to 2.5 cm of soil. No-tilling increased giant foxtail seed over conventional tillage in each year data were collected. Growing corn in a soybean-corn or soybean-wheat-corn rotation reduced giant foxtail seed from corn grown continuously in all three soil depths sampled: 0 to 2.5 cm, 2.5 to 10 cm, and 10 to 20 cm. Although stands of giant foxtail tended to follow soil weed seed counts, crop rotation significantly reduced giant foxtail stand with maximum reduction in the soybean-wheat-corn rotation in all tillage systems. Giant foxtail stands were reduced following wheat in no-tilling, probably because of the allelopathic influence of wheat straw. Corn yields showed weed management levels above minimum control are not justified regardless of tillage and crop rotation.