Ageing is an inevitable biological process accompanied by various physiological changes, and researchers have long sought interventions to promote healthy ageing. This article explores the effects of four natural compounds – omega-3 fatty acids, coenzyme Q10, gingerol and curcumin – on the ageing process. We delve into the scientific literature to examine the potential benefits and mechanisms behind these substances in mitigating age-related conditions. Omega-3’s anti-inflammatory properties, coenzyme Q10’s cellular energy support, gingerol’s antioxidant effects and curcumin’s anti-ageing properties are discussed. By shedding light on the impact of these compounds, this review aims to contribute to a better understanding of how natural substances may play a role in promoting longevity and enhancing the quality of life during the ageing journey.