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1 results

  • Prognostic value of cathepsin L and its inhibitor headpin in oral squamous cell carcinoma

  • T Nakashima, R Yasumatsu, M Masuda, G L Clayman, S Komune
  • Journal:
    The Journal of Laryngology & Otology / Volume 126 / Issue 11 / November 2012
    Published online by Cambridge University Press:
    11 September 2012, pp. 1134-1137
    Print publication:
    November 2012
  • Objective:

    To investigate the clinicopathological and prognostic significance of the expression of cathepsin L and its inhibitor headpin, in oral squamous cell carcinoma.

    Design:

    Immunohistochemical studies were performed on 56 oral squamous cell carcinoma samples. We evaluated the relationship between cathepsin L and headpin expression versus patients' clinicopathological factors and survival.

    Results:

    The group that was positive for cathepsin L expression tended to have positive metastatic neck lymph nodes and a poorer prognosis. Headpin expression was not related to metastasis or prognosis. Well differentiated squamous cell carcinoma had higher levels of headpin expression compared with poorly differentiated squamous cell carcinoma.

    Conclusion:

    Cathepsin L expression is related to the invasive and metastatic potential of oral squamous cell carcinoma.