Field experiments conducted at four locations in Georgia and two locations in Florida during 1992 and 1993 evaluated AC 263,222 application rates and timings, systems, and mixtures for weed control, peanut injury, and yield. All rates of AC 263,222 applied early POST (EPOST) or POST controlled Ipomoea morningglories and smallflower morningglory at least 90%, and purple and yellow nutsedge at least 81%. Florida beggarweed and sicklepod control generally was highest when metolachlor was applied PPI followed by AC 263,222 applied EPOST at 71 g/ha, AC 263,222 at 27 or 36 g/ha plus bentazon plus paraquat applied POST, or with bentazon plus paraquat applied EPOST followed by AC 263,222 applied POST at 36 or 53 g/ha. Acifluorfen and acifluorfen plus bentazon reduced Florida beggarweed and sicklepod control at several locations when applied in mixture with AC 263,222. Common ragweed and hairy indigo control were 85 to 95% with bentazon plus paraquat applied EPOST followed by AC 263,222 applied POST at 36 or 53 g/ha. Highest peanut yields were obtained with treatments providing high levels of weed control.