Here, we present a theoretical model for the global evolution of isolated giant molecular clouds. Accounting for the amount of mass, momentum, and energy supplied by accretion and star formation feedback, we are able to follow the growth, evolution, and dispersal of individual GMCs. We compare our models to observations of GMCs and associated young star clusters in the Large Magellanic Cloud and find good agreement between our model clouds and the observed relationship between Hii regions, young star clusters, and GMCs.