Jabal Aja’ in Saudi Arabia is an Important Plant Area (IPA) in the Arabian Peninsula. This paper describes the flora of the Jabal Aja’ area and provides an up-to-date botanical checklist. It designates the site as an IPA due to the presence of endemic and biogeographically relict species and the function of the site as a bioclimatic refuge. In addition to these conservation assessments, this study discusses socio-economic issues, threats to biodiversity conservation on Jabal Aja’, and the future research required to build upon these preliminary studies.