We consider probability measures supported on a finite discrete interval [0, n]. We introduce a newfinite difference operator ∇n, defined as a linear combination ofleft and right finite differences. We show that this operator ∇n plays a keyrole in a new Poincaré (spectral gap) inequality with respect to binomial weights, withthe orthogonal Krawtchouk polynomials acting as eigenfunctions of the relevant operator.We briefly discuss the relationship of this operator to the problem of optimal transportof probability measures.