Field and greenhouse studies were conducted to evaluate selected PRE-applied herbicides for sprangletop control. In greenhouse studies, oxadiazon and dithiopyr provided excellent (> 89%) red sprangletop (L. filiformis) control. Pendimethalin and metolachlor + atrazine provided good (80–89%) to excellent control for 6 mo and 2 mo during studies 1 and 2, respectively. Isoxaben and atrazine provided poor (< 70%) control during both greenhouse studies. In field studies, good to excellent bearded sprangletop (L. fascicularis) control followed dithiopyr, pendimethalin, metolachlor, and metolachlor + atrazine treatments. Dithiopyr at 0.8 kg ai/ha provided best (> 95%) sprangletop control throughout the 6-mo testing period. Under field conditions, control was inconsistent following oxadiazon with good to excellent control during one study and poor control in another study. Better or equal control than metolachlor + atrazine followed dithiopyr, pendimethalin, and metolachlor alone treatments. Oxadiazon also provided similar or better control than metolachlor+atrazine in three of four studies. Over all studies, dithiopyr provided best sprangletop control, followed by metolachlor, metolachlor + atrazine, pendimethalin, and oxadiazon. Isoxaben and atrazine treatments provided poorest or inconsistent sprangletop control.