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  • 15 - To implant or not to implant: the role of leukaemia inhibitory factor

  • from SECTION 3 - LESSONS FROM ANIMAL MODELS (TRANSGENICS) AND NOVEL TECHNOLOGIES
  • Edited by Hilary Critchley, University of Edinburgh, Iain Cameron, University of Southampton, Stephen Smith
  • Book:
    Implantation and Early Development
    Published online:
    05 June 2014
    Print publication:
    01 June 2005, pp 185-202

  • Summary

    This chapter deals with the role of leukaemia inhibitory factor (LIF) at the time of embryo implantation. LIF is involved in endometrial function in humans and domestic species. The lack of LIF signalling in a pregnant female prevents implantation, showing that the action of LIF in the uterus is essential for this process. The absence of LIF has recently been shown to result in low levels of a number of progesterone-responsive genes in the uterus In LIF-null mice, pinopods do not develop over the apical cell membranes, which remain microvillous up to day 7 of pregnancy. Transcript analysis of expression at the implantation site in LIF-null mice suggests molecular abnormalities associated with the lack of decidualisation. One of the most distinctive aspects of the LIF-null phenotype is the complete absence at the implantation site of expression of oncostatin M (OSM), a member of the interleukin 6 (IL6) family.