Linguists have described the English vocabulary as including Latinate and basic subsystems. In three experiments with a total of 93 participants, we asked whether skilled readers are sensitive to graphotactic differences between these systems. Participants saw pairs of nonwords and were asked to choose the item in each pair that appeared more wordlike. Participants were more likely to select an item with an onset and an ending that suggested the same system than an item with a mismatch. Participants also used the presence of a single versus double medial consonant as a marker of the system to which an item belongs. The results suggest that skilled readers have learned about some of the graphotactic differences between Latinate and basic words and do not treat English as a monolithic system.