Alcoholism is frequently accompanied by comorbidities of drugs of abuse and psychiatric diseases. For example, individuals with schizophrenia are at increased risk for developing substance abuse disorders. The availability of imaging tools has enhanced the appreciation of the effects of chronic and excessive alcohol exposure on the human brain. In-vivo computerized tomography (CT) and magnetic resonance imaging (MRI) studies of alcoholism complement postmortem neuropathological investigations in the search for structural brain abnormalities due to alcoholism. This chapter first reviews the general principles of brain imaging and of images analyses as they pertain to the characterization of appropriate structural regions. Then, it reviews the literature on the effects of alcoholism on brain structure as revealed by brain imaging. In combination with structural imaging, experimental models of alcoholism could be a translational point in identifying mechanisms of alcohol-related brain dysmorphology.