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Within the Large Magellanic Cloud, a hot core is observed associated with the embedded high-mass YSO (IRAS 05195˗6911), known as ST16. Comparative observations with molecular abundances typical of Galactic hot cores are discussed, as is the evidence for a rotating protostellar envelope and outflow cavity. A second LMC source, the prominent star-formation region N113, shows centrally focused star formation with associated point-like mid-infrared emission, masers, and compact HII regions superimposed on extended emission. Gas and dust appear compressed by a complex structure of ionized gas bubbles (prominent in Hα detections) engendered by massive stars in several young clusters. In both ST16 and N113 low-metallicity sources, warm dust appears to inhibit COMs formation and survival, while reaction routes appear broadly comparable with Galactic models.
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