The First Congress of Black Culture of the Americas, held in Cali, Colombia, in August 1977 and organized by Afro-Colombian intellectual Manuel Zapata Olivella, was the first Pan-Africanist conference held in Latin America. This paper examines the obstacles Afro-Latin American activists faced in organizing a racially defined event and analyzes how they articulated their own interpretations of black radical politics. It shows that a Pan-Africanist event in Latin America had to account for ideologies of racial harmony and mixture. Observers throughout the region mobilized these ideas to discredit the First Congress as a racist and illegitimate threat to mestizo nationhood. Afro-Latin American activists used it as a platform to debate and denounce ideologies of racial harmony and mixture which many argued cloaked racism and impeded black mobilization. However, for many of the delegates engaging with black radical politics did not imply an absolute rejection of these ideas, but instead highlighted the varying ways in which Afro-Latin American activists understood and contested these concepts in the 1970s. Many Afro-Latin American delegates, even those who were openly critical of ideologies of racial harmony, called for multiracial forms of solidarity and expressed support for culturally mixed visions of the nation-state.