Within the Special Issue ‘Reaching for allies? The dialectics and overlaps between International Relations and Area Studies in the study of politics, security, and conflicts’, this article investigates the post-2011 changing relationship between International Relations (IR) and Middle Eastern Studies (MES). The article departs from the assumption that the reading and writing of security in, on and from the Middle East and North Africa (MENA) region has historically been trapped between the projection of security from abroad and endogenous security narratives. We argue that within the post-Arab uprisings renewed scholarly attention, with studies on security in, on and from the MENA region expressing an all-time methodological pluralism and the increasing and original application of bottom-up and non-military security understandings to regional security, societal and human security are among the most promising notions for transformative dialogue between IR and MES. In broader theoretical terms, we show how the ongoing debate on post-Weberian notions of statehood and post-Westphalian sovereignty point to an already transformative dialogue between IR and MES. The article illustrates this trend with two case studies – on Tunisia and on Iraq – pointing to changing security concepts reflecting changing security practices.