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5 results

  • Antioxidant effect of pomegranate extract in reducing acute inflammation due to myringotomy

  • V Kahya, A Meric, M Yazici, M Yuksel, A Midi, O Gedikli
  • Journal:
    The Journal of Laryngology & Otology / Volume 125 / Issue 4 / April 2011
    Published online by Cambridge University Press:
    25 February 2011, pp. 370-375
    Print publication:
    April 2011
  • Objective:

    To assess the effect of pomegranate extract on acute inflammation due to myringotomy.

    Design:

    Prospective, randomised study.

    Subjects:

    Thirty Sprague–Dawley rats were divided into three groups. Group one constituted controls. Group two underwent myringotomy. Group three underwent myringotomy and also received 100 µl/day pomegranate extract, via gavage, one day before and two days after surgery. Following sacrifice 48 hours after myringotomy, the animals' right ears were used to determine the concentration of reactive oxygen species, using the chemiluminescence method; left ears were used for histological study.

    Results:

    Reactive oxygen species levels were significantly decreased in group three compared with group two (p < 0.01). The density of inflammatory cells in group three was significantly less than that in group two (p < 0.01). Lamina propria thickness and vessel density were also significantly decreased in group three compared with group two (p < 0.01).

    Conclusion:

    Our results indicate that oral pomegranate extract decreases reactive oxygen species concentration and acute inflammation in the tympanic membrane after myringotomy.

  • Ventilation and clearance of the middle ear

  • D Cohen, D Raveh, U Peleg, Y Nazarian, R Perez
  • Journal:
    The Journal of Laryngology & Otology / Volume 123 / Issue 12 / December 2009
    Published online by Cambridge University Press:
    24 September 2009, pp. 1314-1320
    Print publication:
    December 2009
  • Objective:

    To investigate the ventilation and drainage mechanism of the middle ear.

    Study design:

    Prospective.

    Setting:

    We observed 304 (of 337) middle ears with tympanic membrane perforation or myringotomy (102 normal, 90 with otitis media with effusion and 112 with chronic otitis media); 912 observations were recorded overall. Perforations were covered with solution, creating a fluid film, and inspected for gas bubbling at rest, and for outward and inward movement of the fluid film during swallowing. We also noted the inflammatory condition of the ear (i.e. dry, wet or purulent) and the perforation size.

    Results:

    Ears sometimes reacted differently in various sessions. Due to these differences, reactions were classified as ‘types’ of reactions rather than ‘ears’. We refer to 449 ‘types’ of 304 ears. Spontaneous gas bubbling at rest (indicating gas production) was observed in 98 per cent of normal types, 68 per cent of otitis media with effusion types and 65 per cent of chronic otitis media types. Evacuation towards the eustachian tube was observed in 47 per cent, no movement in 46 per cent and outward movement in 9 per cent. During swallowing, inward movement of the fluid film was observed in 74 per cent of normal types, 41 per cent of otitis media with effusion types and 32 per cent of chronic otitis media types.

    Conclusions:

    We found no support for the theory that the eustachian tube supplies air to the middle ear during swallowing. The normal middle ear produces gas which is evacuated by the Eustachian tube. In ears with otitis media, this mechanism appears to be impaired.

  • CO2 laser myringotomy in children with otitis media with effusion

  • Shih-Hsiang Lin, Chien-Chung Lai, An-Suey Shiao
  • Journal:
    The Journal of Laryngology & Otology / Volume 120 / Issue 3 / March 2006
    Published online by Cambridge University Press:
    25 November 2005, pp. 188-192
    Print publication:
    March 2006

  • Background: The study aimed to evaluate the clinical application of CO2 laser myringotomy in children with otitis media with effusion (OME) under topical anaesthesia in an office setting.

    Methods: Laser myringotomy was performed with the CO2 laser Otoscan (OtoLAM) in 54 children (73 ears) with OME. The procedure on the tympanic membrane was performed under topical anaesthesia using Bonain's solution or 10 per cent Xylocaine (lidocaine) solution for 30 minutes before surgery. A circular perforation was created with a power of 15 W, single pulse duration of 200 msec and a scanned area of 1.9 mm in diameter.

    Results: The mean healing time was 2.51 weeks (range 1–5 weeks). Effusion content was not a predictive prognostic factor for perforation healing time. Perforation location over anterior inferior or posterior inferior quadrants was not a predictive factor for perforation healing time. Xylocaine was the more effective anaesthestic. The OME resolution rate was 73 per cent.

    Conclusion: Laser myringotomy provides intermediate duration middle-ear ventilation. It could be beneficial in selected children with OME.