An influential approach to public communication focuses on changing the preexisting frames of understanding the public brings to issues or introducing new frames to strengthen message acceptance. This chapter explores this approach to communicating developmental science in the work of the FrameWorks Institute together with the National Scientific Council on the Developing Child. The application of “strategic frame analysis” is described to show how an influential messaging strategy was developed by FrameWorks, and the example of framing child mental health illustrates this process. Questions are raised about this approach, including how to define the target audience(s) and the media that influence them, balancing scientific accuracy and policy advocacy in the communication goal(s), and whether there are long-term effects of FrameWorks messaging. The work of the National Scientific Council on the Developing Child is profiled as an implementation of strategic frame analysis to communicating developmental science. The development of the core story of early childhood development and the use of metaphors such as toxic stress, serve and return, and brain architecture are discussed. The chapter concludes with questions and cautions about the framing of developmental science and the influence of values in science communication.