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Diagnostic methods share the same common objectives: what is the location of the disorder? What is the pathology? What is the severity and prognosis? Can the abnormality be monitored? The way in which these questions are related to muscle, the neuromuscular junction and the peripheral nervous system are described. The techniques used in these diagnoses are electromyography and nerve conduction studies. The structures and the application of the techniques to them are shown diagrammatically.
Returning to the diagnostic questions posed in Chapter 1 (Introduction), the methods by which electromyography and nerve conduction studies identify and localise pathology within muscle, nerve and the neuromuscular junction are reviewed. Similarly, the methods of assessing severity are recalled. The facility to monitor conditions is limited. The book ends with the outline Summary Table, presented at the beginning of the book, completed, as promised.
The principles of electromyography, including single-fibre electromyography and nerve conduction studies, are described simply, supported by clear diagrams and screenshots of high quality recordings. After a brief overview of anatomy, physiology, pathology and technical matters including electrodes, amplifiers and volume conduction, the way these principles aid the diagnosis of disorders of nerves, muscles and neuromuscular junctions is explained. The book concludes with the findings in common clinical conditions and explores the concept of normal vs abnormal values. This is an invaluable introductory text for trainees in clinical neurophysiology. Clinicians in specialties such as neurology, orthopaedic surgery, rheumatology, general medicine, physical medicine and rehabilitation will benefit from guidance on selecting patients for referral and assistance with the interpretation of the results. Based on the expertise of an author who has spent 25 years practising and teaching the subject, readers can be assured of a wealth of knowledge within these pages.
Over the past 150 years, regional post-traumatic pain has had various appellations, most recently complex regional pain syndrome (CRPS) and post-traumatic neuralgia (PTN). CPRS appears to be a complex endophenotype of PTN that involves neurogenic inflammation as well as pain. There is increasing evidence that peripheral and central inflammatory cascades triggered by nerve injuries contribute to CRPS and perhaps PTN as well. PTN and CRPS often spread beyond classic individual nerve territories, although when patients are asked to outline the epicenter, or most abnormal area, this frequently identifies a specific nerve injury. The most dramatic CRPS and PTN-associated movement abnormality is fixed distal dystonia. Nerve conduction studies and electromyography are useful in documenting and localizing peripheral nerve damage. Currently, four classes of medications are primary options for chronic CRPS/PTN: tricyclics and serotonin-noradrenaline reuptake inhibitors; opioids; gabapentinoids; and topical or systemic local anesthetics.
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