Skip to main content Accessibility help

We use cookies to distinguish you from other users and to provide you with a better experience on our websites. Close this message to accept cookies or find out how to manage your cookie settings.

Close cookie message
×
  1. Home
  2. Search

Refine search

Refine search

Access:
Content type:
Publication date:
Apply   From and To filters
Subject: Show more
Journals Show more
Publishers: Show more
Societies Show more
Series: Show more
Collections: Show more

Actions for selected content:

Select all | Deselect all
  • View selected items
  • Export citations
  • Download PDF (zip)
  • Save to Kindle
  • Save to Dropbox
  • Save to Google Drive

Save Search

You can save your searches here and later view and run them again in "My saved searches".

Please provide a title, maximum of 40 characters.
Cancel
×

8 results

  • Predicting neuropsychological late effects in pediatric brain tumor survivors using the Neurological Predictor Scale and the Pediatric Neuro-Oncology Rating of Treatment Intensity

  • Alannah R. Srsich, Mark D. McCurdy, Peter M. Fantozzi, Matthew C. Hocking
  • Journal:
    Journal of the International Neuropsychological Society / Volume 30 / Issue 4 / May 2024
    Published online by Cambridge University Press:
    25 September 2023, pp. 380-388
    • Article
      • You have access
      • Open access
    • PDF
    • HTML
    • Export citation
  • Objective:

    The Neurological Predictor Scale (NPS) quantifies cumulative exposure to tumor- and treatment-related neurological risks. The Pediatric Neuro-Oncology Rating of Treatment Intensity (PNORTI) measures the intensity of different treatment modalities, but research is needed to establish whether it is associated with late effects. This study evaluated the predictive validity of the NPS and PNORTI for neuropsychological outcomes in pediatric brain tumor survivors.

    Method:

    A retrospective chart review was completed of pediatric brain tumor survivors (PBTS) (n = 161, Mage = 13.47, SD = 2.80) who were at least 2 years from the end of tumor-directed treatment. Attention, intellectual functioning, perceptual reasoning, processing speed, verbal reasoning, and working memory were analyzed in relation to the NPS and PNORTI.

    Results:

    NPS scores ranged from 1 to 11 (M = 5.57, SD = 2.27) and PNORTI scores ranged from 1 (n = 101; 62.7%) to 3 (n = 18; 11.2%). When controlling for age, sex, SES factors, and time since treatment, NPS scores significantly predicted intellectual functioning [F(7,149) = 12.86, p < .001, R2 = .38] and processing speed [F(7,84) = 5.28, p < .001, R2 = .31]. PNORTI scores did not significantly predict neuropsychological outcomes.

    Conclusions:

    The findings suggest that the NPS has value in predicting IF and processing speed above-and-beyond demographic variables. The PNORTI was not associated with neuropsychological outcomes. Future research should consider establishing clinical cutoff scores for the NPS to help determine which survivors are most at risk for neuropsychological late effects and warrant additional assessment.

  • COVID-19 and its Cardiac and Neurological Complications among Ontario Visible Minorities

  • Joseph Y. Chu, Yosuf Kaliwal, Maria Koh, Robert Chen, Chi-Ming Chow, Dennis T. Ko, Peter P. Liu, Gordon W. Moe
  • Journal:
    Canadian Journal of Neurological Sciences / Volume 49 / Issue 4 / July 2022
    Published online by Cambridge University Press:
    24 June 2021, pp. 504-513
    • Article
      • You have access
      • Open access
    • PDF
    • HTML
    • Export citation
  • Background:

    Due to lack of data on the epidemiology, cardiac, and neurological complications among Ontario visible minorities (Chinese and South Asians) affected by coronavirus disease (COVID-19), this population-based retrospective study was undertaken to study them systematically.

    Methods:

    From January 1, 2020 to September 30, 2020 using the last name algorithm to identify Ontario Chinese and South Asians who were tested positive by PCR for COVID-19, their demographics, cardiac, and neurological complications including hospitalization and emergency visit rates were analyzed compared to the general population.

    Results:

    Chinese (N = 1,186) with COVID-19 were found to be older (mean age 50.7 years) compared to the general population (N = 42,547) (mean age 47.6 years) (p < 0.001), while South Asians (N = 3,459) were younger (age of 42.1 years) (p < 0.001). The 30-day crude rate for cardiac complications among Chinese was 169/10,000 (p = 0.069), while for South Asians, it was 64/10,000 (p = 0.008) and, for the general population, it was 112/10,000. For neurological complications, the 30-day crude rate for Chinese was 160/10,000 (p < 0.001); South Asians was 40/10,000 (p = 0.526), and general population was 48/10,000. The 30-day all-cause mortality rate was significantly higher for Chinese at 8.1% vs 5.0% for the general population (p < 0.001), while it was lower in South Asians at 2.1% (p < 0.001).

    Conclusions:

    Chinese and South Asians in Ontario affected by COVID-19 during the first wave of the pandemic were found to have a significant difference in their demographics, cardiac, and neurological outcomes.

  • The progression of coeliac disease: its neurological and psychiatric implications

  • Giovanna Campagna, Mirko Pesce, Raffaella Tatangelo, Alessia Rizzuto, Irene La Fratta, Alfredo Grilli
  • Journal:
    Nutrition Research Reviews / Volume 30 / Issue 1 / June 2017
    Published online by Cambridge University Press:
    15 December 2016, pp. 25-35
    • Article
      • You have access
      • Open access
    • PDF
    • HTML
    • Export citation

  • The aim of the paper is to show the various neurological and psychiatric symptoms in coeliac disease (CD). CD is a T cell-mediated, tissue-specific autoimmune disease which affects genetically susceptible individuals after dietary exposure to proline- and glutamine-rich proteins contained in certain cereal grains. Genetics, environmental factors and different immune systems, together with the presence of auto-antigens, are taken into account when identifying the pathogenesis of CD. CD pathogenesis is related to immune dysregulation, which involves the gastrointestinal system, and the extra-intestinal systems such as the nervous system, whose neurological symptoms are evidenced in CD patients. A gluten-free diet (GFD) could avoid cerebellar ataxia, epilepsy, neuropathies, migraine and mild cognitive impairment. Furthermore, untreated CD patients have more symptoms and psychiatric co-morbidities than those treated with a GFD. Common psychiatric symptoms in untreated CD adult patients include depression, apathy, anxiety, and irritability and schizophrenia is also common in untreated CD. Several studies show improvement in psychiatric symptoms after the start of a GFD. The present review discusses the state of the art regarding neurological and psychiatric complications in CD and highlights the evidence supporting a role for GFD in reducing neurological and psychiatric complications.

  • Chapter 18 - Controversies surrounding airway management and cesarean delivery

  • Edited by Ian McConachie, University of Western Ontario
  • Book:
    Controversies in Obstetric Anesthesia and Analgesia
    Published online:
    05 December 2011
    Print publication:
    17 November 2011, pp 215-228

  • Summary

    Epidurals are the most effective mode of analgesia for labor pain. Neurological complications, although rare, remain one of the most important causes of anxiety in the parturient and it is important to provide reassurance while providing accurate data for informed consent. Central nervous system (CNS) lesions secondary to epidural analgesia are very rare. They can be classified into four etiologies: traumatic, ischemic, infective, or chemical, or can sometimes be a combination thereof. High-quality evidence supports that there is no causal relationship between epidural labor analgesia and the development of new chronic back pain. High-dose epidural fentanyl may be associated with an adverse effect on breastfeeding. Women who labor with epidural analgesia experience an increase in temperature, which is associated with administration of antibiotics to both mother and babies, increased neonatal sepsis workups, as well as possibly increased operative deliveries.

  • Chapter 14 - Hypoxic-ischemic brain injury

  • Edited by S. Andrew Josephson, University of California, San Francisco, W. David Freeman, David J. Likosky
  • Book:
    Neurohospitalist Medicine
    Published online:
    07 October 2011
    Print publication:
    29 September 2011, pp 181-191

  • Summary

    Perturbation in the balance of electrolytes can cause both central and peripheral neurological symptoms. Hyponatremia can be the most challenging electrolyte abnormality to correctly diagnose. Regardless of etiology, neurological manifestations are more likely to be present in acute rather than chronic hyponatremia because the rapid decrease in extracellular sodium precipitates intracellular fluid shifts and cellular edema. Calcium stabilizes electrically excitable cell membranes in nerve and muscle tissue and its derangements can have significant neurological sequellae. Like calcium, magnesium has a stabilizing effect on electrically excitable cell membranes. Phosphate homeostasis is closely tied to that of calcium. Hyperphosphatemia can result in symptomatic hypocalcemia and ectopic calcification but it does not generally have neurological manifestations. Phosphate can also be depleted in malnourished patients. Prompt diagnosis and correct management are important to prevent neurological and systemic complications of electrolyte derangements.

  • 10 - Conventional digital subtraction angiography for carotid disease

  • from Luminal imaging techniques
  • Edited by Jonathan Gillard, University of Cambridge, Martin Graves, University of Cambridge, Thomas Hatsukami, University of Washington, Chun Yuan, University of Washington
  • Book:
    Carotid Disease
    Published online:
    03 December 2009
    Print publication:
    07 December 2006, pp 126-139

  • Summary

    This chapter reviews the current state of conventional digital subtraction angiography (DSA) in contemporary neurovascular imaging practice, including indications, techniques, complications and comparison with noninvasive techniques. The main indication for carotid DSA in current practice remains the evaluation of carotid atherosclerotic disease and accurate measurement of stenosis. Complications related to DSA can be classified as puncture-site-related, contrast-medium-related or neurological. More problematic complications such as pseudoaneurysms or large hematomas requiring surgical intervention are more infrequent. Several mechanisms have been postulated to account for the occurrence of neurological complications. Several established measurement methods are used to quantify the severity of internal carotid artery (ICA) stenosis prior to revascularization. The North American symptomatic carotid endarterectomy trial (NASCET) method is most widely used in North America, while the European carotid surgery trial (ECST) method tends to be frequently used in Europe.