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Twin-to-twin transfusion syndrome (TTTS) is a complication that affects approximately 10% of all monochorionic twin pregnancies. O'Donoghue et al. reported that majority of stage I cases (67.4%) were managed by amnioreduction, with 39.1% treated at the time of first presentation. Serial amnioreductions may be offered as a treatment for stage I disease for the treatment of patients who are symptomatic from polyhydramnios or have a shortened cervix. In 20% of TTTS cases, amnioreduction may lead to stabilization or regression of the stage. Laser therapy for stage I disease has been offered by many centers due to the risk of progression and the eventual need for a definitive treatment. There are few studies that report outcomes for laser treatment specifically for stage I disease. A consensus conference was sponsored by the North American Fetal Therapy Network to evaluate the available information regarding management of Quintero stage I TTTS.
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