In the nineteenth century, when Italy was undergoing significant institutional and socio-economic changes, the bourgeoisie affirmed its principles of ‘respectability’. In this context, the spread of prostitution among the poorest and most disadvantaged classes of the South became a real obsession for bourgeois society. Through the study of primary sources relating to various health institutions, this paper aims to assess the role of the Opere Pie in the control and management of prostitution. It furthermore highlights the hybrid function of the re-education, assistance and segregation of those women who represented a danger to bourgeois morality and order. Finally, it sheds light on the living conditions and social environment of young prostitutes.