This chapter reviews rare stroke occurrences associated with specific bone disorders. The disorders have been divided into subgroups based on body bone pathology, specific skull diseases, and periodontal diseases. The phenomenon of fibrocartilaginous embolism (FE) is well documented in the veterinary literature. Multifocal ischemic encephalomyelopathy associated with fibrocartilaginous emboli was first described in a lamb by Jeffrey and Weels. Osteopetrosis (OP) is a rare, hereditary metabolic disorder of unknown etiology, characterized by an abnormal accumulation of bone mass, probably caused by diminished bone resorption. Cerebrovascular disorders of these patients have a mainly mechanical origin. Craniosynostosis may be associated with decreased cerebral blood flow as a result of the constriction of the brain because of the prematurely fused sutures. There is a relationship between premature arteriopathy with stroke and Camurati-Engelmann disease (CED). The association between periodontal disease and stroke has several possible pathophysiologic links.