Two field experiments were conducted in Oklahoma to determine whether changing wheat row spacing, seeding rate, and cultivar would reduce interference from rye. Wheat row spacing did not affect rye seed production. Averaged over row spacing, increasing wheat seeding rate from 67 to 134 kg/ha reduced rye seed production 21 and 25% in two experiments. At one site, grain yield of rye-infested wheat was increased 27 and 23% by doubling wheat seeding rate in 10- and 20-cm rows. Doubling the seeding rate of rye-infested wheat in 30-cm rows did not increase wheat yield. At a second site when data were pooled over row spacings, increasing the wheat seeding rate from 67 to 101 kg/ha increased yield of rye-infested wheat 21%, but yield was still 36% less than for rye-free wheat. In two additional experiments, rye seeds in harvested wheat were reduced 36% by increasing the wheat seeding rate from 60 to 162 kg/ha, whereas yield of rye-infested wheat was increased 82%. Nine cultivars were compared for competitive ability against rye in four experiments. Of 32 possible cultivar location situations, the rye-induced yield loss of ‘Jagger’ wheat was less than 16 other cultivar location situations, whereas the yield loss of ‘Triumph 64’ wheat was less than 10 other cultivar location situations. Mature wheat height, wheat yield, and wheat maturity classification were each negatively correlated to rye yield in infested wheat at two of four sites. Wheat plant density, head density, sunlight interception, and fall cover capability classification were each negatively correlated to rye yield at one of four sites.