Field studies were conducted in 1994 and 1995 to determine the contribution of PRE applications of alachlor, metolachlor, acetochlor, SAN 582H, or pendimethalin on woolly cupgrass and wild-proso millet control when followed by POST nicosulfuron at 0, 0.018, 0.027, or 0.036 kg ai/ha. Sequential treatments controlled woolly cupgrass and wild-proso millet greater than single applications of PRE herbicides, which when applied alone resulted in the least wild-proso millet control and lowest corn grain yield. Lack of complete woolly cupgrass control with POST nicosulfuron alone resulted in corn grain yield that was less than with sequential treatments but was equal to PRE treatments. Wild-proso millet control with nicosulfuron at 0.027 kg/ha resulted in corn grain yield that was less than with sequential treatments, but greater than with all PRE treatments except for SAN 582H. All PRE herbicides, regardless of early season performance, when followed by nicosulfuron resulted in woolly cupgrass and wild-proso millet control that was similar. Woolly cupgrass seed production compared to the nontreated check was reduced 98% with acetochlor followed by nicosulfuron. Sequential treatments provided the most consistent woolly cupgrass and wild-proso millet control, the highest corn grain yield, and the greatest reduction in woolly cupgrass and wild-proso millet seed production.