Understanding the recent events marking the late Quaternary history of the Po Plain (N-Italy) is of overriding importance to decipher the record of depositional versus erosional phases, and their interplay with climatic, tectonic, and human forcing. We reconstructed the structural setting and chronostratigraphy of a Holocene succession crosscut by a thrust fault located south of Montodine (Cremona, Italy) within the Po Plain. The fault shows a maximum displacement up to one meter. Radiocarbon dating fixes a minimum age of 11.9 cal ka BP for the postglacial river entrenchment and constrains the fault movement age between 5.9 and 3.4 cal ka BP. Undeformed Late Medieval coarse gravels cover the faulted succession. Due to the outcrop position, lying above the buried frontal thrusts of the Southern Alps and North Apennines, we propose that faulting results from secondary surface effects induced by seismic shaking. We discuss two main mechanisms, both related to lateral spreading, that can result in the formation of reverse faults close to the surface. The Soncino area, recording one of the strongest historical earthquakes of the central Po Plain (1802), is considered as a possible source for seismic shaking. The results of this study are a contribution for the assessment of the potential seismic hazard in one of the most populated regions of Europe.