We developed a 1108 yr chronology of tree-ring widths, based on 64 Himalayan pencil juniper (Juniperus semiglobosa Regel) trees, for the Pamir-Alay Mountains, central Asia. Dendroclimatological analysis demonstrates that precipitation has significant effects on tree growth in the semiarid mountainous area of northwestern Tajikistan located on the edge of the great midlatitude Karakum and Kyzylkum deserts. The highest level of linear correlation (r=0.67) is observed between tree growth and seasonalised winter (previous December–February) precipitation. Our studies also show that moisture (precipitation/Palmer Drought Severity Index) from the previous June to the current September was the dominant climatic factor accounting for interannual variations in tree-ring width, suggesting that this should be considered in climate reconstruction. Using the transfer function method, we reconstructed the region’s drought history over the period AD 908–2015. The results of this moisture reconstruction showed that the most recent millennium was characterised by series of dry and wet stages. The driest periods occurred before 1000, 1200–1250, and at the end of the eighteenth century and beginning of the nineteenth century. The wettest conditions existed in 1650–1700 and after 1990.