This essay documents growing partisan social uprootedness across Latin America over time, manifested in diminishing social trust toward parties, debilitation of links between parties and social collectivities, lowering levels of partisanship, and rising incidence of personalism in the electorate. It focuses on some unrecognized and undertheorized causal factors behind partisan involution in the region, putting emphasis on mutually reinforcing processes. First, it identifies forces endogenous to the traits of origin of diminished parties that foster their uprootedness and decay; second, it lays out some of the manifold ways that the weakening of political parties fuels regime malperformance, in a mutually reinforcing vicious circle; third, it outlines the existence of mutual feedback loops between political agency and structure; fourth, it identifies various agential sources of party decay. There are strong theoretical and empirical reasons to expect continued party deinstitutionalization across Latin America going forward.